Pope Francis, history’s first pope from the global south and a maverick who often delighted the world, died April 21 after fighting pulmonary disease for the last few months.

Just as hundreds of people had gathered at the Vatican each night to recite the rosary when Pope Francis was hospitalized, throngs returned to recite the Marian prayer for the repose of his soul after his death.

Pope Francis died April 21 after suffering a stroke and heart attack, said the director of Vatican City State’s department of health services. The pope had also gone into a coma.

Centuries of experience dealing with the death, or occasional resignation, of a pope has left the Catholic Church with thorough instructions detailing who has responsibility for planning the funeral, preparing for the election of a new pope and taking care of essential business in the meantime.

Here is a timeline of some significant events in Pope Francis’ 12-year pontificate:

President Donald Trump, officials in his administration and other U.S. political leaders issued statements expressing condolences for Pope Francis after the pontiff’s death April 21 at age 88.

A special Mass remembering the late pontiff will be held April 21 at 5:30 p.m. at the Cathedral of Mary Our Queen in Homeland. Pope Francis died earlier that day at the age of 88.

Bishop Adam J. Parker and  Bishop Bruce A. Lewandowski, C.Ss.R., both of whom were appointed bishops by Pope Francis, are remembering their personal encounters with the late pope as inspirational moments that helped shape their ministries. 

Archbishop William E. Lori said that Pope Francis could be readily described as a “pastoral pope,” a sense of service that he brought from his years as an archbishop in Argentina who was close to his priests and people.

Pope Francis’ funeral rites, like those for any pope or any Christian, are meant to “reinforce the hope and witness to the faith” that those who have been baptized in Christ “will rise with him to new life.”